General Hospital (GH) spoilers for Wednesday, May 21, indicate some major moments in the land of Port Charles.

The 2025 Nurses Ball officially kicked off during the Tuesday, May 20 episode, and tomorrow, fans will be privy to all the fun performances.

With that said, viewers should brace themselves for some massive drama between acts.

In fact, Lucy Coe (Lynn Herring) will make her first wardrobe change of the night as she welcomes everyone to the big gala in a sparkling evening gown.

During the GH preview for the May 21 episode, a clip of her is shown promising everyone a night they will never forget.

First off, a scene from the preview shows Curtis Ashford (Donnell Turner) telling Portia Robinson (Brook Kerr) that, “This could destroy everything.”

Yikes! It sounds like he’ll tell her that he knows Drew Cain (Cameron Mathison) is blackmailing her.

What happens next between these two, and will Curtis end up leaving his wife over more lies she’s told?

Speaking of broken-up marriages, General Hospital spoilers for Wednesday’s show hint that Josslyn Jacks (Eden McCoy) will take a page out of her mom, Carly Spencer’s (Laura Wright), playbook when she lashes out at Willow Tait-Corinthos (Katelyn MacMullen).

The preview for tomorrow’s episode shows Josslyn warning Willow that she’ll never take Michael Corinthos’ (last played by Chad Duell) kids away from him.

From the looks of it, Michael is on his way home, so will he reveal himself during Wednesday’s show?

Over to Lulu Spencer (Alexa Havins Bruening), she’ll keep a close eye on Lois Cerullo’s (Rena Sofer) every move.

Thanks to Lois’s bond with Giovanni “Gio” Palmieri (Giovanni Mazza) and constant doting on the young man, Lulu put two and two together about him being Dante Falconeri’s (Dominic Zamprogna) and Brook Lynn Quartermaine-Chase’s (Amanda Setton) son.

During the preview, Lulu seems adamant that she needs conclusive proof and will tell Cody Bell (Josh Kelly) such.

Will these two conduct a secret DNA test without Gio’s or Dante’s knowledge?

Meanwhile, Alexis Davis (Nancy Lee Grahn) will fill Kristina Corinthos-Davis (Kate Mansi) in on being blackmailed by Ava Jerome (Maura West) and Ric Lansing (Rick Hearst).

During tomorrow’s preview, Alexis is shown shouting, “They know what you did, and they can prove it.”

Kristina looks shocked as her mom reveals this, so what happens next between this troubled mother-daughter duo?

In other news, Sonny Corinthos (Maurice Benard) will also issue a warning during the May 21 episode.

The ABC soap’s preview for tomorrow shows him talking to Port Charles’ A.D.A., Justine Turner (Nazneen Contractor), as he makes it clear that no one will run him out of town.

It looks like the mob boss and attorney will have a bit of a confrontation, so here’s hoping they keep it somewhat civil.

Lastly, Anna Devane’s (Finola Hughes) plan will come to fruition, so will her idea work for the Nurses Ball or will it fail?

Fans may recall during the Tuesday, May 20 show, she, along with Lucy and Felicia Scorpio (Kristina Wagner) were down a person for their performance, as Tracy Quartermaine (Jane Elliot) got hauled into the station.

The trio were stressed, so, who will end up replacing her?

General Hospital spoilers hint at plenty of shocking (and fun) moments up ahead, so fans will need to stay glued to their screens as the Nurses Ball continues to roll on!